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Special hazard review with control recommendations for 4,4'-methylenebis (2-chloroaniline).
Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 78-188, 1978 Sep; :1-67
The report reviews current toxicity information on 4,4'-methylenebis (2-chloroaniline) and makes control recommendations. 4,4'-methylenebis (2-chloroaniline) has the formula C13H12C12N2. it is commercially important as a curing agent for diisocyanate-based polymers (polyurethanes) and epoxy resin systems. 4,4'-methylenebis (2-chloroaniline) is used to vary the hardness, flexibility, and impact strength of these products. 4,4'-methylenebis(2-chloroaniline) has been manufactured commercially in the u.s. since 1956. above 200 degrees C, 4,4'-methylenebis(2-chloroaniline), releases irritant and toxic vapors (primarily ortho-chloroaniline). NIOSH estimated through a national survey that in the early 1970's approximately 55,000 u.s. workers were potentially exposed to 4,4'-methylenebis(2-chloroaniline). the majority of these workers were employed in small-to-medium sized establishments where occupational health services may not have been readily available. this review provides an examination of information available in 1973 and a more detailed presentation of recent studies along with recommendations for control of workplace exposures to 4,4-methylenebis(2-chloroaniline).
Toxicology; Industrial-medicine; Hazardous-materials; Exposure-levels; Vapors; Curing-agents; Exposure-levels; Chlorine-compounds; Occupational-health; Maximum-permissible-concentrations
Numbered Publication; Criteria Document
NTIS Accession No.
DHEW (NIOSH) Publication No. 78-188
DCDSD; DSHEFS; DBBS; DPSE
National Institute for Occupational Safety and Health
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division