Current intelligence bulletin 46 - methylene chloride.
NIOSH 1986 Apr; :1-18
B6C3F1 mice exposed to methylene chloride in air developed cancers (alveolar/bronchiolar carcinomas) and tumors (alveolar/bronchiolar adenomas) of the lung, and cancers (hepatocellular carcinomas) of the liver. Fischer 344/N rats exposed to methylene chloride in air developed tumors (fibromas and fibroadenomas) of the mammary gland. Sprague-Dawley rats exposed to methylene chloride in air developed cancers (sarcomas) of the salivary glands and tumors (fibromas and fibroadenomas) of the mammary glands. Though existing epidemiologic data derived from workers exposed to methylene chloride are inconclusive, the observation of cancers and tumors in both rats and mice treated with methylene chloride meets the criteria established in the Occupational Safety and Health Administration (OSHA) Cancer Policy for considering methylene chloride a "potential occupational carcinogen." Therefore, the National Institute for Occupational Safety and Health (NIOSH) recommends that worker exposure to methylene chloride be controlled to the lowest feasible limit.
Cancer; Carcinogens; Carcinomas; Neoplasms; Tumors; Animal-studies; Epidemiology
Numbered Publication; Current Intelligence Bulletin
NTIS Accession No.
(NIOSH) 86-114; CIB 46
National Institute for Occupational Safety and Health