Biological monitoring of organophosphorus pesticide exposure among children of agricultural workers in central Washington State.
Loewenherz-C; Fenske-RA; Simcox-NJ; Bellamy-G; Kalman-D
Environ Health Perspect 1997 Dec; 105(12):1344-1353
A study was conducted examining risk of pesticide exposure among children up to 6 years of age living with a pesticide applicator. Exposure was assessed by determination of dialkylphosphate metabolites and creatinine in urine samples obtained from children who had at least one household member who worked regularly as a pesticide applicator and whose residence was within 200 feet of an orchard or crop, and from children who had no family member working in the agricultural industry and whose residence was more than 200 feet from an orchard or crop (referents). Forty percent of all samples had detectable levels of dimethylthiophosphate (DMTP) and 6.3% had detectable levels of dimethyldithiophosphate. The median DMTP level in exposed children was four times that of reference children. A marginally significant trend of increasing urinary metabolite levels with decreasing age was identified, and in an analysis of 21 sibling pairs, younger siblings had a significantly higher metabolite level than older siblings. An effect of proximity on urinary metabolite concentrations was also observed when the 48 applicator households were classified by distance from a nearby orchard. These results indicate that children living in households with pesticide applicators and in proximity to orchards treated with pesticides have greater exposure to organophosphate pesticides than do children living in families without such exposure and at greater distances from agricultural spraying.
NIOSH-Publication; NIOSH-Cooperative-Agreement; Neurotoxic-effects; Environmental-exposure; Organo-phosphorus-pesticides; Biological-monitoring; Agricultural-chemicals; Exposure-levels; Insecticides
Neurotoxic Disorders; Neurotoxic-effects
Environmental Health Perspectives
University of Washington, Seattle, Washington