Review and update of the results of the NIOSH medical study of workers exposed to chemicals contaminated with 2,3,7,8- tetrachlorodibenzodioxin.
Sweeney-MH; Calvert-GM; Egeland-GA; Fingerhut-MA; Halperin-WE; Piacitelli-LA
Teratog, Carcinog, Mutagen 1997 Jan; 17(4/5):241-247
The results of the NIOSH medical study of occupational exposure to chemicals contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746016) (TCDD) were reviewed and updated. The subjects consisted of 281 workers exposed over 15 years ago to TCDD and 260 age, race, and gender matched referents. The subjects completed questionnaires concerning medical and occupational history and underwent various physical examinations. The mean serum lipid adjusted TCDD concentration was significantly higher in workers than in referents. Serum TCDD concentrations were significantly related to gamma- glutamyltransferase (GGT) concentration, serum testosterone, luteinizing hormone, and follicle stimulating hormone levels, triglyceride and high density lipoprotein (HDL) concentrations, CD3/Ta1 cell count, chloracne diagnosis, and fasting serum glucose concentration. The risk of an out of range GGT concentration was significantly elevated among TCDD exposed workers, with an odds ratio (OR) of 2.27. The risk of diabetes was significantly increased among exposed workers, with OR of 1.12. Fasting serum glucose levels were significantly higher in exposed workers than in referents. The risks of high luteinizing hormone, high follicle stimulating hormone, and low testosterone concentrations tended to increase with increasing serum TCDD level. Serum TCDD concentration was significantly related to triglyceride concentration. Abnormal HDL levels exhibited a moderate, positive relationship with serum TCDD concentration. The risk of chloracne was significantly elevated among workers with the highest serum TCDD levels, with an OR of 2.3. The authors conclude that relatively few adverse health outcomes appear to be associated with TCDD exposure.
NIOSH-Author; Humans; Occupational-exposure; Exposure-levels; Dose-response; Polychlorinated-aromatic-hydrocarbons; Clinical-tests; Clinical-diagnosis; Blood-serum; Blood-analysis; Risk-analysis; Enzyme-activity; Hormone-activity; Serum-cholesterol;
Marie Haring Sweeney, Acting Chief, and Document Development Branch, NIOSH, Mailstop C-15, 4676 Columbia Parkway, Cincinnati, OH 45226
Teratogenesis, Carcinogenesis, and Mutagenesis