Environmental exposures and risk of digestive cancers.
Department of Work Environment, University of Massachusetts at Lowell, Lowell, Massachusetts 1996 Dec; :1-19
The elevated risks for cancer of the esophagus, stomach, pancreas, colon, and rectum previously identified in a cohort mortality study of auto workers with exposure to machining fluids (MF) were examined to identify the specific type of fluids or agents in the fluids associated with these cancers. An existing historical database was expanded to include cumulative exposure based on quantitative estimates of sulfur compounds. Conditional logistic regression models were fit to the case control data for each outcome of interest to examine exposure response associations and provide estimates of the magnitude of risk. Strong evidence was found supporting the duration of exposure to metalworking fluids in grinding operations using either soluble or synthetic fluid, as associated with an elevated risk of esophageal cancer. Exposure to synthetic metalworking fluid was associated with increased risk of pancreatic cancer and straight fluids were associated with rectal cancer. The magnitude of the risks ranged from less than two fold for stomach cancer and solubles up to 5.3 fold for esophageal cancer and grinding with soluble metalworking fluids.
NIOSH-Grant; Cancer; Automotive-industry; Metal-workers; Cancer-rates; Risk-factors; Epidemiology; Gastrointestinal-system-disorders
Work Environment Univ of Lowell Research Fdn 450 Aiken St., Lowell, MA 01854
Final Grant Report
NTIS Accession No.
Department of Work Environment, University of Massachusetts at Lowell, Lowell, Massachusetts
University of Massachusetts Lowell, Lowell, Massachusetts