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Time-related factors in radiation-sancer dose response.
Wing SB; Richardson DB
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 1997 Aug; :1-229
The effects of low level, external exposure to ionizing radiation on the mortality of workers at Oak Ridge National Laboratory (ORNL) were investigated. The retrospective cohort study included 14,095 ORNL workers hired between 1943 and 1972 and followed through 1990. The focus on the analysis was on time related factors which influenced the association between all cancer mortality rates and cumulative external radiation dose. The data indicated that the cumulative dose received after age 45 strongly predicted all cancer mortality among these workers under a range of lag assumptions, and provided estimates of similar magnitude for lung cancer mortality and mortality from cancers other than lung. The cumulative dose received at older ages was more strongly associated with subsequent cancer mortality than lifetime cumulative dose. The strong evidence of a dose response relationship and the substantial magnitude of this association suggest that by considering age at exposure a smaller, more relevant time period of exposure can be identified. The authors suggest that if the effects of low level radiation do indeed increase with age, then differences in radiosensitivity need to be incorporated into considerations of radiation protection, medical uses of radiation, and the implications of industrial and military applications of nuclear technologies.
NIOSH-Grant; Pulmonary-system-disorders; Lung-cancer; Humans; Radiation-exposure; Cancer-rates; Epidemiology; Age-factors; Risk-analysis; Nuclear-radiation; Ionizing-radiation; Occupational-exposure
Epidemiology University of North Carolina Cb#7400 Mcgavran-Greenberg HAl Chapel Hill, NC 27599-7400
Final Grant Report
NTIS Accession No.
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina
University of North Carolina Chapel Hill, Chapel Hill, North Carolina
Page last reviewed: September 2, 2020
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