Health hazard evaluation report: HETA-94-0072-2648, Gen Corp Automotive, Marion, Indiana.
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, HETA 94-0072-2648, 1997 Aug; :1-180
In response to a request from the United Rubber Workers Union, Local 466, an investigation was conducted at Gen Corp Automotive (SIC- 3061), Marion, Indiana. The Union expressed concern regarding employee exposures in all three departments at the facility, the rubber vehicle sealing area, the mix house, and the liquid composite molding area. On site sample collection was performed along with medical interviews, informal conversations with employees, and a review of records. High nitrosamine concentrations were measured in the vehicle sealing department. Concentration of nitrosamines were as high as 16.34 micrograms/cubic meter. A salt bath curing process was generating the nitrosamines, and a combination of insufficient local exhaust ventilation and exhaust reentering the work area was contributing to the build up. No overexposures were noted for other compounds such as volatile organics and aromatic hydrocarbons. DNA adducts in peripheral white blood cells and excised DNA adducts in the urine were studied. A significant correlation was noted between having detectable concentrations of O6-methyldeoxyguanosine adducts in peripheral white blood cells, and the negative correlation between nitrosamine exposure and O6-alkylguanine-DNA- alkyltransferase activity. The author concludes that there was a health hazard from the presence of nitrosamines in this workplace and recommended steps including elimination of the source by reformulation of the rubber stock or redesign of the curing process.
NIOSH-Author; NIOSH-Health-Hazard-Evaluation; NIOSH-Technical-Assistance-Report; HETA-94-0072-2648; Hazard-Confirmed; Region-5; Nitro-compounds; DNA-adducts; Occupational-exposure; Rubber-workers;
Author Keywords: Molded, Extruded, and Lathe-cut Mechanical Rubber Goods; rubber; rubber vehicle sealing; sheet molding compound; nitrosamines; nitrosodimethylamine; NDMA; nitrosopiperidine; NPIP; nitrosomorpholine; NMOR; nitrosodiethylamine; NDEA; nitrosodibutylamine; NDBA; nitrosodipropylamine; NDPA; nitrosopyrrolidine; NPYR; DNA adducts; N7-methyldeoxyguanosine; O6-methyldeoxyguanosine; O6-alkylguanine-DNA alkyltransferase; AGT; volatile organic compounds; VOCs; isocyanates; methylene diisocyanate; MDI
Field Studies; Hazard Evaluation and Technical Assistance
NTIS Accession No.
National Institute for Occupational Safety and Health