Metal fume fever: characterization of clinical and plasma IL-6 responses in controlled human exposures to zinc oxide fume at and below the Threshold Limit Value.
Fine-JM; Gordon-T; Chen-LC; Kinney-P; Falcone-G; Beckett-WS
J Occup Environ Med 1997 Aug; 39(8):722-726
The clinical effects of exposure to zinc-oxide (1314132) at or below the 5mg/m3 threshold limit value were investigated and an attempt was made to track any rise in circulating IL-6 and tumor necrosis factor (TNF) Subjects included 13 healthy nonsmoking volunteers with a mean age of 30.8 years. Subjects were exposed to zinc-oxide fume at 2.5mg/m3 or 5mg/m3, or to air for 2 hours. At 6 to 12 hours after exposure, the mean maximum rise in oral temperature was 1.4+/- 0.3 degrees-F after 5mg/m3, 1.2+/-0.3 after 2.5mg/m3 and 0.6+/-0.5 degrees after air exposure. Plasma levels of interleukin-6 (IL-6) were significantly elevated after exposure to 5mg/m3 zinc-oxide. Mean IL-6 values at preexposure and at 3 and 6 hours after exposure were 1.9, 2.8, and 2.9, respectively, on the air day and 1.6, 4.4, and 6.4 on the 5mg/m3 zinc-oxide day. Zinc-oxide exposure did not significantly affect plasma levels of tumor necrosis factor. Total symptom scores peaked 9 hours after the 5mg/m3 zinc-oxide exposure. Myalgia, cough, and fatigue were the predominant symptoms reported. The authors conclude that inhalation of zinc-oxide for 2 hours at the current threshold limit value of 5mg/m3 produced fever and symptoms along with elevations in plasma IL-6 levels.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Metal-fume-fever; Respiratory-system-disorders; Zinc-compounds; Inhalation-studies; Humans; Toxic-effects
Jonathan M. Fine, MD, Pulmonary and Critical Care Section, Norwalk Hospital, Norwalk, CT 06856
Pulmonary System Disorders
Journal of Occupational and Environmental Medicine
Yale University, New Haven, Connecticut