A workshop was held on the prevention of hypersensitivity pneumonitis (HP). NIOSH had compiled the information available on existing investigations of this problem in eight facilities with cases of HP. The eight facilities manufactured engines, transmissions, electronics, refrigeration equipment, and other components. Ninety eight cases of diagnosed HP were noted in the eight facilities, at least 22 having had lung biopsy and at least 41 had abnormal chest radiographs or computerized tomography scans. In many cases, reversibility of disease had occurred with exposure cessation, allowing the subjects to return to work to jobs with no metalworking fluid exposure, or in some cases to jobs with exposures to different metalworking fluids. Cases of HP were recognized with metalworking fluid exposures of less than 0.5 milligram/cubic meter. The workshop participants identified knowledge gaps of risk factors, exposure response relationships, intervention efficacy, and natural history, as well as needs for surveillance to define the extent of the problem. The authors conclude that guidance for prevention is limited in the absence of answers to these questions.
NIOSH-Author; Humans; Metalworking-industry; Occupational-exposure; Industrial-factory-workers; Metal-workers; Oil-mists; Cutting-oils; Respiratory-system-disorders; Machinists; Respiratory-hypersensitivity; Chemical-hypersensitivity;
Author Keywords: metalworking fluid; machining fluid; hypersensitivity pneumonitis; mycobacteria; occupational respiratory disease; granulomatous disease