The diversity of reaginic immune responses to platinum and palladium metallic salts.
Biagini RE; Bernstein IL; Gallagher JS; Moorman WJ; Brooks S; Gann PH
J Allergy Clin Immunol 1985 Dec; 76(6):794-802
Direct skin test sensitivity to platinum (7440064) was evaluated in 107 current and 30 former precious metal refinery workers. The former workers had quit or been discharged because of platinum related health problems. By use of sera of these workers, radioimmunosorbent test (RAST) analysis was performed to assess the presence of platinum specific immunoglobulin-E (IgE) antibodies. Monkey passive cutaneous anaphylaxis was carried out to evaluate what types of reaginic immune responses were involved. Possible palladium (7440053) sensitivity was also evaluated. Fifteen of the current workers (14%) exhibited positive skin tests, as indexed by immediate reactivity at a dose of 10(-3) gram/milliliter or less. Of the former workers no longer exposed to platinum, eight (27%) also demonstrated positive platinum skin tests. The data confirmed that soluble platinum salt hypersensitivity is mediated by reaginic immune mechanisms that in some cases were of long duration. Several workers also demonstrated concomitant platinum and palladium reaginic specific antibodies. The presence of heat stable/short term and heat labile/long term sensitizing antibodies to both platinum and palladium salts indicated that the reaginic immune response generated by these compounds is heterogeneous.
NIOSH-Publication; NIOSH-Contract; Contract-211-80-0021; Contract-211-79-0041; Metal-workers; Metal-refining; Metal-dusts; Dust-exposure; Skin-sensitivity; Immune-reaction; Immune-system; Hypersensitivity
Journal of Allergy and Clinical Immunology