Cytogenetic study of workers exposed to ethylene dibromide.
Case studies in occupational epidemiology. Steenland K, ed. New York: Oxford University Press, 1993 Jan; :142-156
A cytogenetic study of papaya packing facility workers in Hawaii was conducted to investigate the health effects of exposure to the fumigant ethylene-dibromide (106934) (EDB), particularly regarding cancer. This study was described as part of a text book and took the reader through the same steps that the investigator took when conducting the actual study to allow the student to solve the same problems that the investigator solved in the course of the study. The first step was to conduct an industrial hygiene survey characterizing exposure at six papaya packing facilities. A total of 60 workers from the papaya facility and 40 nonexposed workers from a nearby sugar facility participated. The industrial hygiene survey confirmed that the papaya facility workers were exposed to levels of EDB averaging about 100 parts per million (ppm). Exposure levels differed for three principal job categories, sorter/packer, forklift operator, and fumigator. Further analysis compared length of exposure, and whether or not the workers had skin contact or smelled the chemical. The results indicated that at these relatively low levels of exposure, there was no association with sister chromatid exchange frequencies, indicating there was no cytogenetic effect for these workers.
Genotoxic-effects; Chromosome-disorders; Chromosome-damage; Risk-factors; Epidemiology; Occupational-exposure; Food-processing-industry
Case studies in occupational epidemiology