A vinyl chloride case-control study.
Case studies in occupational epidemiology. Steenland K, ed. New York: Oxford University Press, 1993 Jan; :66-75
Investigators examined the reports of an earlier study of liver cancers occurring at a polyvinyl-chloride (9002862) (PVC) facility in Louisville, Kentucky to determine whether exposure could cause cancers at other sites, principally the lung and brain. This study was described as part of a text book and took the reader through the same steps that the investigator took when conducting the actual study to allow the student to solve the same problems that the investigator solved in the course of the study. A new cohort mortality study was conducted of all male workers at the site, not just those exposed to vinyl-chloride (75014) gas. The cohort was restricted to workers between 1942 and 1973 and had follow up through 1986. The study findings indicated that workers exposed to vinyl-chloride gas experienced a significant excess of liver cancer, particularly the rare angiosarcoma of the liver. This excess was related to the cumulative dose of vinyl-chloride gas. Other cancers suspected a-priori were not found to be associated with exposure to vinyl-chloride gas. Exposure to polyvinyl-chloride dust was not found to be related to either liver, lung, or brain cancer incidence.
Cancer-rates; Liver-cancer; Lung-cancer; Respiratory-system-disorders; Risk-factors; Dust-exposure; Toxic-gases; Occupational-exposure; Epidemiology
Case studies in occupational epidemiology