Pulmonary effects of machining fluid aerosols.
Department of Internal Medicine, University of Iowa, Iowa City, Iowa 1997 Jan; :1-21
The relative toxicity of three major classes of machining fluids (soluble, synthetic and semisynthetic) was compared in an animal model of pulmonary injury and inflammation. Significant differences in toxicity were noted in guinea-pigs after a single 3 hour exposure suggesting that various types of machining fluids may have inherent differences in toxicity in the workplace. Greater toxicity was noted in guinea-pigs exposed for 3 hours to used machining fluid aerosols compared to aerosols of unused fluids. Physicochemical properties of machining fluids were also found to contribute to adverse pulmonary effects. Little to no pulmonary injury or inflammation was noted in guinea-pigs exposed to 5mg/m3 used machining fluid aerosols for 30 days. Three daily exposures of rats to 20mg/m3 used machining fluid aerosols produced a significant increase in stored mucosubstances in the epithelial lining of the intrapulmonary airways and the nasal septum. These findings suggest that irritant components of machining fluids can contribute to the increase in sputum and chronic bronchitis reported for workers exposed to machining fluid aerosols.
NIOSH-Grant; Pulmonary-system-disorders; Respiratory-system-disorders; Laboratory-animals; Inhalation-studies; Cutting-oils; Toxic-effects
Environmental Medicine New York University Medical Ct Long Meadow Road Tuxedo, NY 10987
Final Grant Report
NTIS Accession No.
Department of Internal Medicine, University of Iowa, Iowa City, Iowa
New York University, New York, New York