Pentoxifylline does not alter the response to inhaled grain dust.
Jagielo-PJ; Watt-JL; Quinn-TJ; Knapp-HR; Schwartz-DA
Chest 1997 May; 111(5):1429-1435
The effects of pentoxifylline (PTX) on airway inflammation and lung function following inhalation of grain dusts was studied. Lung function tests and bronchoscopy were performed following a challenge with corn dust extract (CDE) in ten healthy human subjects treated with 400 milligrams PTX or placebo three times daily for 4 days and a single dose of PTX or placebo on the day of testing. Subjects in both the PTX and placebo groups experienced similar frequencies of acute respiratory and systemic symptoms following CDE exposure. Inhalation challenge with CDE similarly and significantly reduced the forced expiratory volume at 1 second and the forced vital capacity and acutely increased total cell and neutrophil concentrations and levels of tumor necrosis factor alpha and interleukin-8 in bronchoalveolar lavage fluid in both PTX and placebo treated subjects. Peripheral blood leukocyte and neutrophil counts were significantly higher in both groups of subjects following CDE exposure. The authors conclude that PTX did not alter the physiologic and inflammatory response to CDE in these subjects.
NIOSH-Publication; NIOSH-Cooperative-Agreement; Agriculture; NIOSH-Grant; Pulmonary-system-disorders; Therapeutic-agents; Lung-function; Grain-dusts; Respiratory-irritants; Alveolar-cells; Respiratory-hypersensitivity; Blood-cells
Internal Medicine University of Iowa 200 Hawkins Drive Iowa City, IA 52242-1081
Grant; Cooperative Agreement
University of Iowa, Iowa City, Iowa