The hardware and software basis of the Neurobehavioral Evaluation System, version 3 (NES3), and the development of a battery for computer based tests designed specifically for screening individuals were described. The computer based system was designed to assist the clinician in deciding whether individual workers exposed to potential neurotoxicants should be referred for more expensive full scale clinical neuropsychological assessment. It was intended to allow a standardized, efficient, cost effective method to be used in occupational medicine and public health, detecting subclinical neurotoxic effects and preventing additional harmful exposures. Two separate pilot studies of the NES3 were performed. In the first, 29 outpatients at the Emory Occupational Medicine Program were recruited to evaluate the functionality of the screening test software and hardware. The second study included a sample of convenience of 38 older, community dwelling men. The tests were completed satisfactorily by each of the study groups. The tests covered a range of cognitive domains including verbal list learning and recognition memory, visual memory span, conceptual and motor racing, psychomotor speed and accuracy, and delayed verbal recognition.
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