Immunotoxicity - bridging the gap between animal research and human health effects.
Selgrade-MK; Cooper-KD; Devlin-RB; Loveren-H; Biagini-RE; Luster-MI
Fundam Appl Toxicol 1995 Jan; 24(1):13-21
Issues concerning the extrapolation of experimental immunotoxicity data to human health effects were discussed. Research has suggested that conservation of the immune system across species lessens reservations regarding this practice. Studies on the immunotoxic effects of exposure to ultraviolet radiation and ozone (10028156) in experimental animals and humans were reviewed to illustrate the consistency between species. Ultraviolet radiation has been shown to induce local immune suppression and immunologic tolerance in both humans and in mice; however, systemic suppression which has been demonstrated in mice has not been seen in humans. Human and mouse macrophages have also been shown to behave almost identically in response to ozone exposure in-vitro and in-vivo. The contributions of various mouse models of severe combined immunodeficiency disorder (SCID) to current knowledge regarding human SCID were described and discussed. Problems associated with the determination and interpretation of immunotoxic effects in human population studies were explored.
NIOSH-Author; Immunotoxins; Analytical-methods; Animal-studies; Comparative-toxicology; Ultraviolet-radiation; Toxic-effects; Irritant-gases; Humans
Fundamental and Applied Toxicology