Interactions of radiofrequency radiation on 2-methoxyethanol teratogenicity in rats.
Nelson-BK; Conover-DL; Shaw-PB; Snyder-DL; Edwards-RM
J Appl Toxicol 1997 Jan; 17(1):31-39
The interactive effects of radiofrequency (RF) radiation and 2- methoxyethanol (109864) (2-ME) exposure were observed in rats. Mated female CD-Sprague-Dawley-rats were exposed to RF radiation at a frequency of 10 megahertz (MHz) for up to 30 minutes and gavaged with 2-ME at concentrations ranging from 0 to 140mg/kg on gestational day 13. On day 20, the dams were killed and the fetuses were removed and analyzed for external and skeletal malformations. Dose related developmental toxicity was seen for 2-ME, either with or without RF radiation. The dose effect curve of 2-ME was altered by concurrent RF radiation exposure. The authors conclude that, when developing exposure guidelines and intervention strategies, the potential combined effects of exposure should be included in the assessments.
NIOSH-Author; Laboratory-animals; Toxic-effects; Radiation-exposure; Reproductive-effects; Prenatal-exposure; Ethylenic-alcohols; Dose-response;
Author Keywords: 2-methoxyethanol; ethylene glycol monomethyl ether; methyl cellosolve; radiofrequency radiation; nonionizing radiation; pregnancy; developmental toxicology; teratology
B. K. Nelson, Division of Biomedical and Behavioral Science, NIOSH C-24, Cincinnati, OH 45226, USA
Journal of Applied Toxicology