Proceedings of the International Symposium on Health Hazards of Glycol Ethers, 19-21 April, 1994, Pont a Mousson, France.
The toxicity of the glycol ethers and the management of hazards from exposure to them were considered in this symposium. Topics included metabolism, toxicokinetics, biomonitoring, exposure assessment, reproductive and developmental effects, genotoxic and epigenetic effects, hematotoxic and immunotoxic effects, general toxicity, human data from the semiconductor industry, other human exposure, and risk assessment. In the area of metabolism, toxicokinetics and biomonitoring, articles covered the characterization of urinary metabolites, metabolism of diglyme by rat hepatocytes and human microsomes, assessing hemolysis risk following 2-butoxyethanol (111762) exposure, a physiologically based pharmacokinetic model of 2-methoxyacetic-acid (625456) deposition, and in-vitro metabolism of glycol ethers by human and rat hepatocytes. Exposure assessment included atmospheric and biological monitoring, ground water contamination, use patterns of glycol ethers, and house painter exposure. Reproductive and developmental effects included embryo dosimetry and teratogenic responses, detection of testicular toxicity, evaluation of developmental toxicity, and Drosophila developmental toxicology. Genotoxic and epigenetic effects included a review of properties of ethylene-glycol ethers. Hematotoxic and immunotoxic effects focus on the immunotoxicity of 2-methoxyethanol and its metabolites, the induction of apoptosis in the rat thymus, and effects of butoxyacetic-acid (2516930) on human red cells. Also considered were general toxicity, human exposures in the semiconductor industry, and risk assessment.