The authors respond to comments by Nathan et al (1996) on their research on the national prevalence of self reported carpal tunnel syndrome (CTS) among US workers (American Journal of Industrial Medicine, Vol. 28, pages 451-470, 1995, NIOSH-00225950). The authors address comments regarding the subjective nature of the data and calculation of the prevalence of self reported (SR) CTS among recent workers compared to nonrecent workers. While subjectivity is a common problem among questionnaire surveys, reasonable estimations and conclusions based on the data are still valid. Although CTS diagnosis was not confirmed with nerve conduction tests, clear distinctions were observed between individuals with 'medically called' CTS and those with hand discomfort only. In addition, the prevalence of 'medically called' CTS determined in this study was similar to the findings of other investigations. With respect to comparing the prevalences of SR-CTS in recent and nonrecent workers, the authors state that the methodology used accounted for the fact that the samples used were not truly independent and was adjusted for any possible correlation between the two prevalences. The effects of personal factors, such as age, sex and race, on prevalences were also briefly discussed.