Immunotoxicity: hazard identification and risk assessment.
Luster MI; Kimber I
Hum Exp Toxicol 1996 Dec; 15(12):947-948
This report provided commentary on data presented and issues discussed at a meeting of the British Toxicology Society Immunotoxicology and Allergy Specialty Section held in April of 1996. Operationally, immunotoxicity was defined as the adverse health effects resulting from functional impairment of the immune system after exposure to xenobiotics has occurred. Debate rages concerning the most appropriate methods for identifying potential immunotoxicants in the context of routine toxicological studies. Studies conducted with over 50 chemicals has yielded a very extensive database now collated and analyzed with the objective being to improve testing configuration such as to ensure the accurate identification of potential immunotoxicants. A major concern has been to what extent do changes in immune parameters translate into alterations in host resistance and an increased susceptibility to infectious or malignant disease. One study series demonstrated that using regression modeling, most, but not all, immune function host resistance relationships followed a linear model. Much progress has been made in refining more completely the most appropriate means for assessing potential immunotoxic activity and in characterizing the relationship between altered immune function and the experimental measurement of compromised host resistance.
NIOSH-Author; Immunology; Toxic-effects; Risk-analysis; Immune-system-disorders; Metabolic-study; Physiological-response; Host-resistance
MI Luster, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
Human and Experimental Toxicology