Lung injury and fibrogenic response to dusts from citrus and grape harvests.
Rajini-P; Last-JA; McCurdy-SA; Lawson-R; Southard-RJ; Allamneni-KP; Witschi-H
Inhal Toxicol 1995 Apr; 7(3):363-376
Dusts from leaf surfaces in vineyards and citrus groves were evaluated during harvest season for fibrogenic potential in rats. Using a canopy, dust from leaves was collected during harvest from three orchards and three vineyards. Male Sprague-Dawley-rats received intratracheal instillations of the dust samples suspended in saline, and lung lavage fluid was collected for analysis 3 days later. None of the dusts produced a significant increase in protein content of lung fluid. Both dusts produced an increase in total number of cells recovered from lung lavage fluids, which was significant for one of the vineyard dusts. A significantly higher percentage of polymorphonuclear leukocytes occurred for citrus orchard dust exposed rats. Biochemical analysis of lung tissue showed that vineyard dust, but not orchard dust, had fibrogenic potential. The authors conclude that their findings may be important for human epidemiologic data, and future studies should confirm the effect of vineyard dust to cause fibrotic lung changes with chronic exposure.
NIOSH-Publication; NIOSH-Cooperative-Agreement; Laboratory-animals; Dust-exposure; Dust-inhalation; Dust-particles; Airborne-dusts; Pulmonary-system-disorders; Agricultural-products;
University of California - Davis