Long-term ambient concentrations of particulates and oxidants and development of chronic disease in a cohort of nonsmoking California residents.
Abbey-DE; Lebowitz-MD; Mills-PK; Petersen-FF; Beeson-WL; Burchette-RJ
Inhal Toxicol 1995 Jan; 7(1):19-34
Multipollutant analyses were conducted to determine which pollutant was most strongly or indirectly associated with a disease. The 3,914 participants were members of the Seventh Day Adventist Health Study who lived in urban California. The incidence of cancer and myocardial infarction was determined between 1977 and 1982. Ambient air pollution concentrations were estimated from interpolating statewide air monitoring stations. No statistically significant associations were found between any health outcomes and sulfur- dioxide (7446095) or nitrogen-dioxide (10102440). No associations were found between any ambient pollutants and incidence of malignant neoplasms in men. The incidence of myocardial infarction was significantly associated with levels of sulfur-dioxide above 6 micrograms/cubic meter. Total suspended particulates (TSP) showed the strongest associations of any pollutants with development of airway obstructive disease and chronic bronchitis. For asthma, TSP, ozone (10028156), and sulfur-dioxide were close competitors. TSP was significantly related to incidence of all malignant neoplasms in women, but not men. Ozone was significantly related to development of asthma in men but not women. The authors conclude that statistically significant associations between disease outcomes and particulate pollution is seen at levels that frequently occur in urban areas of California.
NIOSH-Author; Air-quality; Airborne-particles; Epidemiology; Toxic-gases; Respiratory-system-disorders; Cardiovascular-system-disorders; Nitrogen-compounds; Environmental-pollution; Pollutants
7446-09-5; 10102-44-0; 10028-15-6