A NIOSH workshop on work related skin diseases and exposure assessment was summarized. The goal of the workshop was to identify key workplace related research issues and data gaps in exposure assessment, epidemiologic and prevention oriented issues, and laboratory based biomedical research. Major issues covered in laboratory based skin biology included mechanisms of occupational skin disorders (OSDs), molecular genetics, barrier functions and repair, and interactions of skin and respiratory irritancy and sensitization. Major issues in exposure assessment and hazard control research included absorption measurements, biomarker development, dose estimation, data standardization, sensor development, training and education, dermal exposure model validation, and documentation of control measure effectiveness. Major issues in epidemiology and surveillance of OSDs included communication of the risk, cross sectional prevalence studies and prospective studies, intervention studies, evaluation of the impact of worker education on outcome, effectiveness of secondary and tertiary preventive intervention, human response studies, improving data collection systems, refinement of the Sentinel Event Notification System for Occupational Risks (SENSOR), promotion of the Health Hazard Evaluations program, and reexamination of the Sentinal Event Monitoring Program.