Genetics of age-related hearing loss in mice. III. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss.
Erway-LC; Shiau-W; Davis-RR; Krieg-EF
Hear Res 1996 Apr; 93(1-2):181-187
The purpose of this study was to test the hypothesis that putative genotypes for age related hearing loss (AHL) may make mice more susceptible to noise induced hearing loss (NIHL). The inbred CBA/CaJ (CB) and hybrid CBB6F1 strains of mice exhibited only temporary threshold shift with rapid recovery after exposure to 110 decibels for 1 or 2 hours, and they exhibited no evidence of any AHL. The inbred C57BL/6J-mice (B6) and hybrid B6D2F1-mice demonstrated extensive permanent threshold shift and subsequent onset of AHL. The B6-mice had normal auditory evoked brainstem response thresholds from 1 to 2 months of age, but they show gradual progressive elevation of thresholds for high frequencies. By the time they were 5 to 6 months old, threshold elevations were significant above 20 kilohertz. The authors conclude that the major differences observed for permanent threshold shift in the B6 and B6D2F1-mice and the minimal temporary threshold shifts in the CB and CBB6F1-mice support the hypothesis for a major genetic difference among these strains. The findings demonstrated the advantages of using inbred and F1 hybrid strains of mice which are genetically well defined, numerous and readily available.
NIOSH-Author; Laboratory-animals; Noise-induced-hearing-loss; Ear-disorders; Hearing-loss; Age-factors; Hearing-threshold; Genetic-factors;
Author Keywords: Noise-induced; Age-related; Brainstem; Inbred; Hybrid; Mice
University of Cincinnati