The effects of paternal exposure to exogenous agents on offspring behavior or neurochemical alterations in experimental animals were reviewed. The agents reviewed in this report included age, alcohols, cyclophosphamide (50180), ethylene-dibromide (106934), lead (7439921), opiates, cocaine (50362), ethyl-methanesulfonate (62500), mitomycin-C (50077), and procarbazine (671169). Most of the studies of ethyl-alcohol (64175) indicated that paternal exposure produced hyperactivity in the offspring. Several studies have implicated exposure to cyclophosphamide with neurobehavioral deficits in children. Studies with ethylene-dibromide were suggestive of effects in offspring following paternal exposures, but there was only one laboratory which had investigated this finding. The authors suggest that additional replicatable studies be performed. Lead induced changes in early gene expression in early embryos, as well as alterations in hippocampal development of late fetal and early neonatal rats have been reported. Water maze performance of mice was adversely affected by the paternal exposures to opiates. Cocaine exposure to adult male Long-Evans-rats produced offspring with hyperactivity and a decreased capacity for avoidance learning.