An ongoing project, initiated by NIOSH and intended to identify and examine hazardous occupational conditions, was described. Primarily, 177 occupational safety and health professionals and 252 NIOSH researchers were asked to identify specific occupations, exposures, and working conditions which jeopardized the health of workers. Of these 429 individuals, 25% responded, offering a total of 350 individual suggestions for hazard topics. The ten topics nominated most often by both participant groups combined were ergonomics, hazardous waste sites, maintenance activities, construction, agriculture, silica (14808607), indoor air quality, healthcare workers, noise, and lead (7439921). These findings were used to create the National Occupational Research Agenda. Factors which were considered to further prioritize research activities included the number of workers affected, the toxicological or physical severity of the hazard, epidemiological evidence, current standards or sampling techniques, environmental controls, the scarcity of data, and existing scientific resources. The authors conclude that the above topics will be useful in focusing future research. An annual update of the research agenda is planned.