Biomarkers to detect radiation exposures.
Kelsey-KT; Wiencke-JK; Liber-HL
Biomarkers and occupational health: progress and perspectives. Mendelsohn ML, Peeters JP, Normandy MJ, eds. Washington, DC: Joseph Henry Press, 1995 Jun; :215-225
The detection of radiation exposure using biological markers among exposed workers was discussed, with the focus on worker health monitoring. Several assays which were effective in detecting worker exposure were discussed which involved nonspecific lymphocyte, cytogenetic, or genetic mutation analyses. Of particular interest was the development of molecular biomarkers with the capability of distinguishing exposure between ionizing radiation and specific toxic chemicals. Current approaches to the development of biological markers were discussed, including those which could detect specific mutational events. Previous studies demonstrating specific chromosomal abnormalities corresponding to histological subtypes of leukemias or other human cancers were described. The use of mutational spectra in biomarker development was also discussed. Base pair substitutions, insertions, deletions, and larger chromosomal changes may be included in mutational spectra. The use of HPRT mutants in the detection of radiation signature lesions was emphasized and described in detail. The authors conclude that such biomarkers can be used in the detection of radiation specific exposure.
NIOSH-Grant; Grants-other; Biological-monitoring; Occupational-exposure; Radiation-exposure; Ionizing-radiation; Chromosome-damage; Occupational-medicine
Environmental Health Harvard School of Public Hlth 665 Huntington Avenue Boston, MA 02115
Mendelsohn-ML; Peeters-JP; Normandy-MJ
Biomarkers and occupational health: progress and perspectives
Harvard University, Boston, Massachusetts