Glycol ethers: new data, new questions.
Cicolella-A; Hardin-BD; Johanson-G
Occup Hyg 1996 Jan; 2(1-6):1-2
The biological effects of glycol ethers were reviewed in the proceedings of a 1996 meeting. Reports from 200 individuals from 17 countries illustrated the worldwide interest in glycol-ether toxicity. At the first 1983 meeting, practically no information was known about human health effects. Recent studies in occupationally exposed humans associated lower molecular weight ethylene-glycol- ether with reduced semen quality in men and spontaneous abortions in women, as well as possible birth defects and impaired hematopoiesis. Even in 1996, chronic toxicity studies remained lacking. Suggested genotoxic and epigenetic effects of glycol-ether remained speculative and in need of supportive data. Assessment of human exposure made important progress, and analytical methods for urinary metabolites improved biological monitoring. Ground water posed a possible hazard for some, and deserved further study. The authors conclude that international collaborations will enhance knowledge of glycol-ether health effects to people.
NIOSH-Author; Ethers; Ethylenes; Glycols; Reproductive-hazards; Occupational-hazards; Toxic-effects; Occupational-health