2-Ethoxyethanol and 2-methoxyethanol - developmental toxicity in Drosophila.
Occup Hyg 1996 Jan; 2(1-6):171-174
To further evaluate the usefulness of the Drosophila bioassay, a study was conducted to investigate how fruit-flies respond to treatment with 2-ethoxyethanol (110805) (2EE) and 2-methoxyethanol (109864) (2ME). 2EE and 2ME were dissolved in distilled water and mixed with Drosophila medium prior to use. Exposures were continuous from the egg through the third instar larvae. Treatment with 2EE resulted in a statistically significant increase in the incidence of wing blade notches in exposed flies at all exposure concentrations. A statistically significant increase in the incidence of bent humeral bristle defects was observed in flies exposed to all concentrations of 2ME. The authors suggest that these findings indicate that the Drosophila bioassay can be used to accurately identify glycol ethers with known developmental toxicity. These findings also suggest that this assay could serve as a prescreen for assessing the developmental toxicity of other glycol ethers not yet evaluated. Use of this prescreen could serve to prioritize chemicals for developmental toxicity evaluations in mammals.
NIOSH-Author; Organic-solvents; Bioassays; Insects; Glycols; Reproductive-hazards; In-vivo-study; Developmental-disorders