Introduction: the role of biomarkers in the prevention of occupational disease.
Biomarkers and occupational health: progress and perspectives. Mendelsohn ML, Peeters JP, Normandy MJ, eds. Washington, D.C.: Joseph Henry Press, 1995 Jun; :1-6
A framework was presented for considering and using biomarkers in the prevention of occupational disease. Biomarkers may serve to test the effectiveness of primary prevention efforts. In secondary prevention efforts, monitoring may be used for collecting evidence of exposure or for early disease detection. Through the use of biomarkers, it may be possible to address the problems of exposure misclassification, late disease, and failure to account for host factors. Through biomarkers it may be possible to trace back to the middle of the continuum in the natural progression of disease and start to identify preclinical or subclinical events which may indicate early disease events. Markers are now available that indicated increased probability of proceeding from one step to the next in disease development. The authors conclude that no matter how biomarkers are used, there is a need to notify workers not only of their own biomarker test results, but of the overall study results employing biomarkers, as workers have a right to know how their own results fit into the general context of such tests.
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