An evaluation of possible parameters suitable for predicting the ability of organic solvents to penetrate glove materials was performed. A survey of published mathematical models for predicting the permeability of organic solvents through gloves made of nitrile, neoprene, neox-supported neoprene (N-neoprene), polyvinyl-alcohol, polyvinyl-chloride (PVC), and natural rubber was done to identify the equation that could be readily used to predict breakthrough times (Tbr) of solvents such as aniline (62533), ethyl-acetate (141786), pyridine (110861), butyl-alcohol (71363), isobutyl-alcohol (78831), acetone (67641), or methylethylketone (78933). An equation that described the barrier (the glove) as a small chromatographic column which mimicked a relatively polar stationary polar phase solid support in contact with a nonpolar eluent solvent as the penetrant was chosen for analysis. The equation expressed the breakthrough time of a specific solvent through the glove material relative to the Tbr of a reference solvent as a function of the Snyder eluent strength (Eo) of both solvents, the area of stationary phase solid support required by the absorbed solute, and the average surface activity of the stationary phase solid support. The equation was used in conjunction with published values of the Hildebrand solubility parameter, dielectric constant, the octanol/water partition coefficient, the n-heptane/water partition coefficient (log Phep), and the chloroform/water partition coefficient of aniline and the other solvents to predict their Tbrs through the various glove materials. Methyl-alcohol (67561) was used as the reference solvent. The predicted values were compared with published Tbrs measured using the American Society for Testing Materials permeation cell technique. The best results were obtained when Eo and log Phep were used as dependent variables. Both Eo and log Phep were able to qualitatively distinguish between permeation and resistance to penetration of neoprene, PVC, and N-neoprene glove materials against a series of monofunctional alcohols. The author concludes that Eo and log Phep best discriminate resistance to organic solvent permeation of glove materials from penetration. Since Eo and log Phep show the best correlation of the examined parameters, they may describe similar phenomena.