The biological effectiveness of radon-progeny alpha particles. V. Comparison of oncogenic transformation by accelerator-produced monoenergetic alpha particles and by polyenergetic alpha particles from radon progeny.
Miller-RC; Richards-M; Brenner-DJ; Hall-EJ; Jostes-R; Hui-TE; Brooks-AL
Radiat Res 1996 Jul; 146(1):75-80
To investigate methods of assessing the health risks associated with radon in indoor environments, a study was undertaken to compare the rates and mechanisms of oncogenic transformation caused by accelerator produced monoenergetic alpha particles and by polyenergetic alpha particles from radon and its progeny. A range of alpha particle energies with linear energy transfers (LETs) between 70 and 200 kiloelectron volts per micrometer were used to irradiate C3H-10T1/2 cells. Cells of this stock were also exposed to alpha particles from radon and its progeny. The irradiated cultures were scored for oncogenic transformation as an end point. The results showed good agreement between oncogenic transformation experiments using cells exposed either to monoenergetic alpha particles or to polyenergetic radon and its progeny. The authors conclude that this good agreement provides some confirmation to the technique of using transformation rates obtained from monoenergetic alpha particles to predict a rate for an alpha particle spectrum.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Radon-daughters; Health-hazards; Indoor-air-pollution; Radiation-exposure; Radiation-levels; Risk-analysis; Cancer-rates; Oncogenicity; Neoplastic-transformation; Indoor-environmental-quality
Radiology Columbia University Health SCi 630 West 168Th St New York, NY 10032
Columbia University New York, New York, New York