NIOSHTIC-2 Publications Search
Toxigenic molds in water-damaged buildings: dechlorogriseofulvins from Memnoniella echinata.
Jarvis BB; Zhou Y; Jiang J; Wang S; Sorenson WG; Hintikka L; Nikulin M; Parikka P; Etzel RA; Dearborn DG
J Nat Prod 1996 Jun; 59(6):553-554
A cluster of cases of pulmonary hemosiderosis was reported in infants in Cleveland, Ohio, which resulted in an investigation of dampness in the homes of these infants as a common factor. In each home, varying levels of contamination by Stachybotrys-atra was found. Two isolates of Memnoniella-echinata were also noted whose cultures proved cytotoxic against fetal feline lung cells. One isolate was grown on rice for 30 days, extracted and chromatographed providing a number of fractions several of which were highly cytotoxic. Two of the fractions yielded trichodermol (2198938) and trichodermin (4682502). A low cytotoxic fraction yielded dechlorogriseofulvin and epidechlorogriseofulvin. The production of such a wide variety of cytotoxins and immunosuppressants contributes significantly to the toxicity of these organisms.
NIOSH-Author; Cytotoxins; Neonates; Mycotoxins; Microorganisms; Environmental-exposure; Respiratory-system-disorders; Epidemiology; Fungi; Risk-factors; Lung-disease
Issue of Publication
Journal of Natural Products
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Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division