Monitoring of aromatic amine exposures in workers at a chemical plant with a known bladder cancer excess.
Ward-EM; Sabbioni-G; DeBord-DG; Teass-AW; Brown-KK; Talaska-GG; Roberts-DR; Ruder-AM; Streicher-RP
J Natl Cancer Inst 1996 Aug; 88(15):1046-1052
Aromatic amine exposure was monitored in workers at a chemical factory with a known bladder cancer excess. The levels of 4- aminobiphenyl (92671) (4-ABP) in the hemoglobin (Hb) of study participants were measured. A total of 64 workers employed in the rubber chemicals department participated; 52 workers in another department served as unexposed controls. Personal air sampling for aniline (62533) and o-toluidine (95534) was conducted, a questionnaire survey was administered, urine samples and blood samples were collected, and aniline/Hb and o-toluidine/Hb adducts were determined. A total of 73 workers (46 exposed workers and 27 unexposed workers) had data for both aniline and o-toluidine and Hb adducts. Results showed that exposure to aniline and o-toluidine was ubiquitous throughout the rubber chemicals department. Exposed workers were absorbing substantial quantities of aniline and o- toluidine during the workshift. The air concentration, urinary excretion, and adduct levels of o-toluidine were two to three times higher than those of aniline. The exposures to aniline and o- toluidine were highly correlated. Workers in the unexposed department had potential exposure to o-toluidine, since urine levels post shift were higher than pre shift levels. Although there was no widespread contamination of the work area with 4-ABP, contact with the process chemicals at one point in the process might result in low levels of 4-ABP. Workers in the exposed department had adduct levels 100 to 1,000 times greater than those of unexposed workers. The authors conclude that, even at exposure levels below the permissible limit, substantial absorption of aniline and o-toluidine may occur.
NIOSH-Author; Amines; Chemical-manufacturing-industry; Bladder-cancer; Blood-samples; Air-sampling; Questionnaires; Rubber-workers; DNA-adducts; Occupational-exposure;
92-67-1; 62-53-3; 95-53-4;
DSHEFS; DBBS; DPSE
Journal of the National Cancer Institute