Behavioral teratology investigation of tertiary-butanol administered by inhalation to rats.
Nelson BK; Brightwell WS; Khan A; Shaw PB; Krieg EF Jr.; Massari VJ
Pharmacopsychoecologia 1991 Jan; 4(1-2):1-7
A study was conducted of physical and behavioral fetal side effects following exposure of pregnant Sprague-Dawley-rats to tertiary- butanol (75650). Tertiary-butanol was administered by inhalation at concentration levels of 12,000 and 6,000mg/m3 to pregnant female rats throughout their gestation period. Exposures were also made to adult male rats subsequently mated to control females. The offspring were treated for neuromotor coordination, activity, and learning. Brains from ten offspring per exposure group were dissected and assayed for protein and the neurotransmitter acetylcholine, dopamine, norepinephrine, serotonin, met-enkephalin, B-endorphin, and substance-P. Maternal toxicity was apparent, but only limited behavioral or neurochemical effects were noted in the offspring on tests conducted through 90 days of age. The authors conclude that exposure to tertiary-butanol does not appear to produce remarkable behavioral or neurochemical deviations in offspring at the concentrations tested.
Organic-solvents; Solvent-vapors; Developmental-disorders; Teratogenesis; Laboratory-animals; Prenatal-exposure; Inhalation-studies;
Author Keywords: Alcohols; t-butanol; t-butyl alcohol; Tertiary alcohols; Developmental neurotoxicology; Behavioral teratology; Fetal alcohol syndrome
B.K.Nelson, National Institute for Occupational Safety and Health, C-24, Division of Biomedical and Behavioral Science, 4676 Columbia Parkway, Cincinnati, OH 45226, U.S.A.