Restrictive lung function and asbestos-induced pleural fibrosis. A quantitative approach.
Schwartz-DA; Galvin-JR; Yagla-SJ; Speakman-SB; Merchant-JA; Hunninghake-GW
J Clin Invest 1993 Jun; 91(6):2685-2692
The use of a computer algorithm for the three dimensional reconstruction of high resolution computerized tomography chest scans in asbestos (1332214) exposed subjects was described. The three dimensional reconstruction was used to determine the volume of asbestos induced pleural fibrosis in the subjects. Of the 60 subjects studied, fibrosis was identified in the scans from 29. The volumes of the pleural lesions within this group ranged from 0.01% to 7.11% of the total chest cavity. Comparison of the computer derived estimate of pleural fibrosis with total lung capacity indicated an inverse relationship between these measures. This relationship remained in a multivariate analysis controlling for factors such as age, height, cigarette smoking, and the presence of interstitial fibrosis and independently accounted for 9.5% of the variance of this measure of lung volume. Each milliliter of pleural fibrosis was found to be independently associated with a 5 milliliter decrement in total lung capacity. The authors conclude that these data support an independent association between pleural fibrosis and restrictive lung function.
NIOSH-Grant; Pulmonary-system-disorders; Computer-models; Lung-function; Asbestosis; Lung-fibrosis
Internal Medicine University of Iowa Pulmonary Disease Division Iowa City, IA 52242
Pulmonary System Disorders
Journal of Clinical Investigation
University of Iowa, Iowa City, Iowa