Issues in adult and developmental toxicological research were discussed. The discussion considered similarities and differences between adult and developmental neurotoxicological research. Research interests in adult and developmental neurotoxicity show considerable overlap in that both investigate the adverse effects of exogenous agents on the nervous system, primarily the central nervous system (CNS). Both subdisciplines have investigated neurotoxic effects in humans and experimental animals utilizing neurobehavioral, neurochemical, neuropathological, and electrophysiological techniques. Most of the research has been focused on the effects of chemical agents, although some studies have investigated the effects of physical agents such as radiation. Significant differences have existed, however, between adult and developmental neurotoxicological research. Neurotoxicological research conducted in adults has a longer history than developmental research. Adult neurotoxicological research has involved direct experimentation on humans, whereas developmental research has not. The only human component in developmental neurotoxicological research comes from its incidental appearance in epidemiological studies. Adult neurotoxicological research has placed considerable emphasis on exploring mechanisms for observed neurotoxic effects. By contrast, developmental neurotoxicology is still at the stage of just identifying drugs and chemicals that may be neurotoxic and characterizing the toxicity. Very little mechanistic research has been performed.
Neurotoxic-effects; Prenatal-exposure; Developmental-disorders; Behavioral-testing; In-vivo-study; Toxic-effects; Laboratory-animals; Age-factors;
Author Keywords: Neurotoxicology; Developmental neurotoxicology; Prenatal exposures; Perinatal exposures; Behavioral teratology; Children; Pregnancy; Behavioral toxicology; Behavioral pharmacology