Among United States working women, homicide was a leading manner of death from occupational trauma for the period 1980 through 1985, accounting for 42% of fatal injuries at work. Women represented 47% of the work force. The victims of occupational homicide were 16 to 93 years of age; women aged 20 to 34 accounted for 46% of the victims. Women over 65 had the highest age specific homicide rate. The most common cause of death was assault by firearms, with 604 deaths, 64%. Additionally, 181 (19%) died from stabbings and slashings, 69 (7%) from asphyxiation, 57 (6%) from blunt force injuries, and 34 (4%) from fires, explosions, motor vehicle crashes, poisonings, sexual assaults, or other causes. Of the women in the study, 389 (41%) were employed in retail trade and 186 (20%) were employed in service industries. Of the total number of victims, 675 (71%) were employed in one or four categories: sales personnel, 179 (19%); clerical workers 172 (18%); service employees including public safety employees, 172 (18%); and executives, managers or administrators including many self employed women, 152 (16%). The mean number of homicides peaked from December through March with a smaller peak during July and August. Fatal injuries occurred most frequently from 4 to 5 in the afternoon.