Toxicokinetics and metabolism of delayed neurotoxic organophosphorus esters.
Neurotoxicology 1983 Jan; 4(1):113-129
The metabolism, neurotoxic effects and excretion of organophosphorus esters were reviewed and discussed. Tri aromatic organophosphorus esters discussed included tri-o-cresyl-phosphate (78308) and tri-p- ethylphenyl-phosphate. Aliphatic aromatic organophosphorus esters discussed included phenylphosphonothioates, leptophos (21609905), and EPN (2104645). Among the aliphatic organophosphorus esters, the review provided information concerning O,O- diisopropylphosphorofluoridate (55914), S,S,S-tri-N-butyl- phosphorotrithioate (78488), and S,S,S-tri-N-butyl- phosphorotrithioite (150505). Studies have indicated that rodents metabolize and excrete neurotoxic organophosphorus esters efficiently. Adult chickens, however, have difficulty carrying out these processes. The cat is between the rodents and chickens in efficiency. The author concludes that the hen model may exaggerate the effect of neurotoxic organophosphorus esters. Therefore, extrapolating findings from the chicken to man may overestimate the risk or hazard to humans of exposure to organophosphorus esters. The author suggests that the pharmacokinetics and metabolism of organophosphorus esters may be important factors in species and age related sensitivities for organophosphate induced delayed neurotoxicity. Animals that are sensitive to delayed neurotoxicity have a higher accumulation rate, coupled with slower elimination of the neurotoxic agent.
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Nervous-system-disorders; Organo-phosphorus-compounds; Pesticides; Neuropathology; Metabolic-study; Comparative-toxicology
Pharmacology Duke University Department of Pharmacology Durham, N C 27710
78-30-8; 21609-90-5; 2104-64-5; 55-91-4; 78-48-8; 150-50-5
Neurotoxic Disorders; Neurotoxic-effects
Duke University, Durham, North Carolina