Vascular effects of chelation in lead-exposed workers.
Occupational Health Clinic, Division of Occupational and Environmental Medicine, University of California, San Francisco, California 1995 Oct; :1-46
The effect of chelation in lead (7439921) exposed, hypertensive workers on vascular reactivity as monitored by changes in blood pressure response to infused norepinephrine was investigated. Three black workers and one Caucasian worker who had been exposed to lead underwent inpatient dietary equilibration, and were given a stepped dose infusion of norepinephrine just before and just after each experimental intervention of EDTA chelation or placebo. Each subject also underwent a noninvasive assessment of bone lead concentration. There was no significant effect of chelation on vascular reactivity in these lead exposed, hypertensive workers. K- X-ray fluorescence measurements of lead in bone were made in 31 male workers with known lead exposure, and a chelation challenge test was performed in 28. The K-X-ray fluorescence measurement was found to be a better marker of long term lead exposure than the chelation test. In a group of 101 individuals with only limited occupational lead exposure, the age and sex related increases in bone lead concentration were consistent with the kinetics of bone turnover and secular trends in lead exposure. The author concludes that K-X-ray fluorescence measurements are superior to chelation challenge tests as markers of long term lead exposure.
NIOSH-Grant; Cardiovascular-system-disorders; Lead-poisoning; Occupational-exposure; Biological-monitoring; Chelating-agents
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Final Grant Report
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Occupational Health Clinic, Division of Occupational and Environmental Medicine, University of California, San Francisco, California
University of California San Francisco, San Francisco, California