Chronic neurologic sequelae to cholinesterase inhibition among agricultural pesticide applicators.
Ames-RG; Steenland-K; Jenkins-B; Chrislip-D; Russo-J
Arch Environ Health 1995 Nov; 50(6):440-444
Neurobehavioral tests, nerve conduction tests, vibrotactile sensitivity tests, a postural sway test, and a clinical examination were used to investigate possible neurologic sequelae of exposure to cholinesterase inhibiting pesticides in 45 male pesticide applicators in California. The subjects were identified from records of the California medical supervision program and from laboratories certified for medical monitoring. All 45 subjects had a prior history of documented cholinesterase inhibition below worker removal thresholds, but without frank poisoning. Ninety male subjects without past cholinesterase inhibition formed the comparison group. Of the 27 neurologic measures, only one (serial digit performance) was statistically significant; prior cholinesterase inhibition was associated with enhanced performance on this test. According to the authors, these results indicated that preventing acute organophosphate poisoning also prevents neurologic sequelae.
NIOSH-Author; Occupational-exposure; Cholinesterase-inhibitors; Chronic-toxicity; Neurotoxic-effects; Humans; Agricultural-workers; Neuromotor-function
Richard C. Ames, Ph.D., California Environmental Protection Agency, Office of Environmental Health Hazard Assessment, 2151 Berkeley Way, Annex 11, Berkeley, California 94704
Archives of Environmental Health