The genetics of noise-induced hearing loss.
Davis-RR; Erway-LC; Cortopassi-G
Sixth US-Finnish Joint Symposium on Occupational Health and Safety, People and Work, Proceedings of the Sixth FIOH-NIOSH Joint Symposium on Occupational Health and Safety, 8-10 August 1995, Espoo, Finland. People and Work - Research Reports 3. H. Nordman, J. Starck, A. Tossavainen, E. Viikari-Juntura, eds. Helsinki, Finland: Finnish Institute of Occupational Health; 1995 Aug; :31-34
The differences in susceptibility to noise induced hearing loss (NIHL) which may be attributed to genetic factors were discussed. The use of genetic, inbred strains of mice as models for hearing studies was explained; the advantages of using a murine model included small size, easy breeding, short time between generations, production of identical offspring, and the fact that much of their genome has been mapped for homologies with the human genome. The use of various strains in studies of genes and age related or noise related hearing loss was described. Studies were underway to characterize the effect of noise on the ahl-1 genotypes. Human implications associated with these studies were discussed. The authors conclude that by identifying human genes responsible for noise sensitivity, it may be possible to warn workers prior to noise exposure and to prevent NIHL. Workers who may have particular sensitivity to NIHL would be provided with higher levels of hearing protection or by working shorter amounts of time in noisy situations.
Genetic-factors; Noise-exposure; Risk-factors; Laboratory-animals; Noise-induced-hearing-loss; Age-factors; Hearing-loss; Genetics
Nordman-H; Starck-J; Tossavainen-A; Viikari-Juntura-E
Sixth US-Finnish Joint Symposium on Occupational Health and Safety, People and Work, Proceedings of the Sixth FIOH-NIOSH Joint Symposium on Occupational Health and Safety, 8-10 August 1995, Espoo, Finland. People and Work - Research Reports 3