A study was undertaken to determine the association between lung function and occupational gas, dust and fume exposures as assessed by job exposure matrices. Lung function was gauged by spirometric measurements of forced expiratory volume (FEV1). Data from the French Pollution Atmospherique et Affections Respiratoires Chroniques survey were used. Information from 10,046 adults on such factors as occupational exposure, smoking habits, education level, lung function, and air pollution exposure were analyzed. Results were grouped according to reported occupation, and levels of health hazard exposure were classified into no, low, and high exposure categories. Data were subjected to linear regression and analysis of variance. Occupational dust, gas, and/or fume exposure was reported by 23% of male respondents and 19% of female respondents. A clear exposure response relationship was found between level of exposure to dusts, gases, and chemical fumes and a decrease in FEV1. Correlations with FEV1 were found to be very likely for hazards such as organic and textile dusts, polycyclic aromatic hydrocarbons, detergents, and possible for hazards such as solvents, waxes, polishes, and diesel fumes. Associations were still significant in women after adjustment for educational level, but not for men. The authors conclude that job exposure matrices hold promise for the assessment of occupational exposures.