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Soft tissue sarcoma and non-Hodgkin's lymphoma in workers exposed to phenoxy herbicides, chlorophenols, and dioxins: two nested case-control studies.

Authors
Kogevinas M; Kauppinen T; Winkelmann R; Becher H; Bertazzi PA; Bueno-de-Mesquita HB; Coggon D; Green L; Johnson E; Littorin M; Lynge E; Marlow DA; Mathews JD; Neuberger M; Benn T; Pannett B; Pearce N; Saracci-R
Source
Epidemiology 1995 Jul; 6(4):396-402
Link
https://doi.org/10.1097/00001648-199507000-00012
NIOSHTIC No.
00229400
Abstract
A study was conducted on the risk of soft tissue sarcoma and nonHodgkin's lymphoma among an international cohort of workers exposed to phenoxy herbicides or chlorophenols. Data on mortality of phenoxy herbicide or chlorophenol exposed workers due to soft tissue sarcoma and nonHodgkin's lymphoma were obtained from the International Agency for Research on Cancer. Excess risk for soft tissue sarcoma was seen for those exposed to any phenoxy herbicides, such as 2,4-dichlorophenoxyacetic-acid (94757) (2,4-D), 2,4,5- trichlorophenoxyacetic-acid (93765) (2,4,5-T), 4-chloro-2- methylphenoxyacetic-acid (94746), to any polychlorinated dibenzodioxin or furan, and to 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746016) (TCDD). A dose response relationship was observed for 2,4- D, 2,4,5-T, TCDD, and any polychlorinated dibenzodioxin. Associations of chemical exposure with nonHodgkin's lymphoma were generally lower than those seen for soft tissue sarcoma. Excess risk for exposure to 2,4,5-T, TCDD, and polychlorinated dibenzodioxins or furans was approximately twofold for this disease while a threefold increased risk was observed for exposure to pentachlorophenol (87865) or gamma-butyrolactone (96480). Dose response relationships were identified for lymphoma and 2,4,5-T and any polychlorinated dibenzodioxin or furan.
Keywords
NIOSH-Author; Cancer-rates; Mortality-rates; Mortality-data; Pesticides; Chlorinated-phenols; Occupational-exposure; Dioxins; Polychlorinated-hydrocarbon-pesticides; Author Keywords: soft tissue sarcoma; non-Hodgkins lymphoma; phenoxy herbicides; dioxin; case-control study
CODEN
EPIDEY
CAS No.
94-75-7; 93-76-5; 94-74-6; 1746-01-6; 87-86-5; 96-48-0
Publication Date
19950701
Document Type
Journal Article
Fiscal Year
1995
Issue of Publication
4
ISSN
1044-3983
NIOSH Division
DSHEFS
Source Name
Epidemiology
State
OH
Page last reviewed: May 11, 2023
Content source: National Institute for Occupational Safety and Health Education and Information Division