"That which is crooked cannot be made straight" (1): Response to J. S. Puskin.
Brenner DJ; Hall EJ
Radiat Res 1994 Apr; 138(1):144-145
A previously published report describing methods for the determination of health risks associated with domestic exposure to radon (10043922) was questioned in this letter to the editor. The authors took exception to the use of a linear representation of risk and cumulative radon exposure for the extrapolation of findings obtained in studies of miners exposed at high doses to low dose domestic exposures leading to the conclusion that the data for miners underestimate the true risk. The basis for the authors' argument was evidence that has suggested that the dose response relationship of radon differs at different doses. This relationship has been reported to be linear at low doses; however, the authors contend that the true shape of the dose response curve should be convex, rather than linear, at the high doses seen in the studies of miners from which the curve in the study questioned was derived.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Radiobiology; Dose-response; Exposure-levels; Radiation-exposure; Analytical-methods
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