Biological monitoring of commercial pesticide applicators for urine metabolites of the herbicide alachlor.
Sanderson-WT; Biagini-R; Tolos-W; Henningsen-G; MacKenzie-B
Am Ind Hyg Assoc J 1995 Sep; 56(9):883-889
The urinary excretion of alachlor (15972608) metabolites was measured in the urine of 20 commercial pesticide applicators and seven hauler/mixers exposed to the compound using an enzyme linked immunosorbent assay (ELISA) as well as high performance liquid chromatography (HPLC). The workers were employed by commercial pesticide application companies. Three urine samples were collected over a 24 hour period. The results obtained using the ELISA and the HPLC were well correlated although the ELISA gave consistently higher measurements. Similar concentrations of alachlor metabolites were seen in the urine of applicators and hauler/mixers. The intersubject variability in metabolite levels could not be correlated with pounds of alachlor handled and applied, numbers of acres sprayed, or time spent handling the compound. Urinary alachlor metabolite levels were near or below the limits of detection of the assays in a comparison group of eight workers with limited pesticide exposure.
NIOSH-Author; Herbicides; Agricultural-chemicals; Agricultural-workers; Occupational-exposure; Metabolic-study; Analytical-methods; Urinalysis; Chromatographic-analysis
American Industrial Hygiene Association Journal