NIOSHTIC-2 Publications Search

Validity of computerized tests in occupational settings.

White RF; Letz R; Feldman RG; Gendzier RD
Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 1995 Jan; :1-60
A study was designed to assess the validity of the Neurobehavioral Evaluation System (NES) tests as measures of central nervous system function in subjects with well defined neurologic disorders. A total of 237 subjects were administered the NES battery and three traditional neuropsychological tests. These persons were included in three main subject groups: Parkinson's disease (PD); multiple sclerosis (MS); and focal cortical lesions (FL). The FL group included patients with anterior left, anterior right, posterior left, and posterior right conditions. The study also had as a goal to determine whether there are patterns of impaired performance on specific subtests of the NES which are associated with each of these conditions. It was found that it is indeed feasible to administer the NES battery to a population of neurological patients when they are selected so as to meet stipulated exclusion criteria. Control subjects performed significantly better overall than did patient groups, confirming the sensitivity of the NES to central nervous system (CNS) pathology. The sensitivity of the battery as a whole and of particular tests differed for the various patient groups. The battery was relatively insensitive to substantia nigra dysfunction associated with PD. NES tests were extremely sensitive to white matter dysfunction, as noted with MS patients in the majority of cognitive domains assessed. The battery was also sensitive to cortical FL. The authors note that the findings obtained here with patients with known neurologic disease indicate the direction in which improvement of the breadth and sensitivity of the battery must proceed if it is to fulfill its purpose.
NIOSH-Grant; Neurotoxic-effects; Nervous-system-disorders; Neuropathology; Brain-function; Brain-damage; Behavioral-tests
Neurology Boston University 80 East Concord Street Boston, MA 02118
Publication Date
Document Type
Final Grant Report
Funding Amount
Funding Type
Fiscal Year
Identifying No.
NIOSH Division
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts
Performing Organization
Boston University, Boston, Massachusetts
Page last reviewed: February 25, 2022
Content source: National Institute for Occupational Safety and Health Education and Information Division