Department of Environmental Health Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 1994 Apr; :1-9
The results of study concerning the dose/response relationship for occupational exposures to styrene were presented in this final performance report. A year long assessment of exposure to styrene (100425) was performed for a cohort of 48 workers in a fiberglass boat manufacturing facility. Assessment involved measuring styrene in air, exhaled air, and blood. Methods were developed for measuring adducts of styrene-7,8-oxide (96093) (SO) with proteins and with DNA in the blood. Estimates of the individual mean exposures to styrene ranged between 0.9 and 235mg/m3 for the 48 subjects, with an overall mean of 84.2mg/m3. There was a high degree of correlation between the estimated mean levels of styrene in the blood and exhaled air, and the exposure to styrene. There was also a significant correlation with sister chromatid exchanges (SCEs) and styrene exposure, even after controlling for cigarette smoke. The investigation optimized the analytical procedures for SO adducts with hemoglobin, serum albumin, and lymphocyte DNA. Statistically significant correlations were found between the mean exposure to styrene for each subject and the corresponding mean levels of several biomarkers. The authors note that this is the first example of a longitudinal investigation in which exposure to a genotoxic substance was measured along with a variety of biomarkers. The design of the study reduced measurement error in styrene exposure to an extent which allowed the authors to detect elevated levels of SCEs at styrene concentrations well below those which had been previously reported. The authors suggest that in the reinforced plastics industry styrene measurement in air is likely to be more efficient than that of biomarkers to determine the relationship between genotoxic effects and exposure to styrene.
We take your privacy seriously. You can review and change the way we collect information below.
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.
Cookies used to make website functionality more relevant to you. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.
Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data.
Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These cookies may also be used for advertising purposes by these third parties.