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Hydrocarbon Exposure and Chronic Renal Disease.
Department of Biostatistics and Epidemiology, Health Sciences Center, University of Oklahoma 1993 Dec:44 pages
A case/control study was conducted to investigate the role of chronic exposure to hydrocarbons in causing chronic renal disease. The study population included patients with chronic renal disease and matched controls identified from the metropolitan areas of Oklahoma City and Tulsa, Oklahoma. Altogether, 321 matched pairs were studied. Patients had either chronic renal disease with a diagnosis of idiopathic chronic glomerulopathy or chronic renal failure with an unknown primary disease. There was no significant difference between cases and controls regarding lifetime occupational hydrocarbon exposure, mean scores being 165 parts per million (ppm) and 162ppm, respectively. The hydrocarbon exposure was categorized into a dichotomous variable using a cutoff point set at 100ppm based on the opinion of the study industrial hygiene team. Subjects were considered to be exposed if they had a score of more than 100ppm and nonexposed if the score was below 100ppm. Cases had a higher proportion of exposed subjects than controls, but the difference was not statistically significant. Even after controlling for possible confounders, there was no significant difference found for the overall comparison between cases and controls. The authors conclude that there was no significant association found between renal disease and hydrocarbon exposure. However, there was a significant association found within the subgroup of solvent agents and degreasers, and unclassified diagnosis.
NIOSH-Grant; Grants-other; Organic-solvents; Solvent-vapors; Aromatic-hydrocarbons; Kidney-damage; Renal-toxicity; Occupational-exposure;
Biostatistics and Epidemiology University of Oklahoma 801 NE 13Th St, P O Box 26901 Oklahoma City, Okla 73190
Final Grant Report;
NTIS Accession No.
Other Occupational Concerns; Grants-other;
Department of Biostatistics and Epidemiology, Health Sciences Center, University of Oklahoma
University of Oklahoma Hlth Sciences Ctr, Oklahoma City, Oklahoma
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division