Influence of lead on mineralization during bone growth.
Fundam Appl Toxicol 1995 Jul; 26(2):265-271
A study was conducted on the effects of lead (7439921) on the mineralization of cartilage in developing bones. Ectopic bone growth was induced by the subcutaneous implantation of control or lead containing demineralized bone matrix into Long-Evans-rats and lead deposition, alkaline-phosphatase activity, and cartilage mineralization were assessed. In addition, the effects of lead were studied in animals implanted with control bone matrix and exposed to lead in their drinking water. The gross appearance of lead containing osteoinductive bone matrix following implantation was identical to that seen following implantation of nonosteoinductive matrix indicating no development of normal ectopic bone. In contrast, hard tissue consistent with bone development was seen in animals implanted with control osteoinductive bone matrix. Animals implanted with lead containing matrix did not demonstrate alkaline- phosphatase activity or cartilage mineralization and had markedly increased levels of calcium (7440702) deposition. Animals exposed to lead in their drinking water demonstrated decreased alkaline- phosphatase activities and enhanced cartilage calcification. The authors conclude that these results suggest that disruption of bone mineralization during growth may be a mechanism by which lead exerts its adverse effects on bone development.
NIOSH-Publication; NIOSH-Grant; Reproductive-system-disorders; Lead-compounds; Heavy-metals; Toxic-effects; Bone-structure; Bone-disorders; Laboratory-animals
Environmental Health University of Cincinnati 3223 Eden Avenue Cincinnati, OH 45267
Fundamental and Applied Toxicology
University of Cincinnati, Cincinnati, Ohio